Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections.

Distinct Roles of Type I and Type III Interferons in Intestinal Immunity to Homologous and Heterologous Rotavirus Infections.

Type I (IFN-α/β) and type III (IFN-λ) interferons (IFNs) exert shared antiviral activities through distinct receptors. However, their relative importance for antiviral protection of different organ systems against specific viruses remains to be fully explored. We used mouse strains deficient in type...

Full description

Bibliographic Details
Main Authors: Jian-Da Lin, Ningguo Feng, Adrish Sen, Murugabaskar Balan, Hsiang-Chi Tseng, Constance McElrath, Sergey V Smirnov, Jianya Peng, Linda L Yasukawa, Russell K Durbin, Joan E Durbin, Harry B Greenberg, Sergei V Kotenko
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1005600

Internet

https://doi.org/10.1371/journal.ppat.1005600

Similar Items