Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion

Perturbed maintenance of transcriptional repression on the inactive X-chromosome in the mouse brain after Xist deletion

Abstract Background The long noncoding RNA Xist is critical for initiation and establishment of X-chromosome inactivation during embryogenesis in mammals, but it is unclear whether its continued expression is required for maintaining X-inactivation in vivo. Results By using an inactive X-chromosome-...

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Bibliographic Details
Main Authors: Robin L. Adrianse, Kaleb Smith, Tonibelle Gatbonton-Schwager, Smitha P. Sripathy, Uyen Lao, Eric J. Foss, Ruben G. Boers, Joachim B. Boers, Joost Gribnau, Antonio Bedalov
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Epigenetics & Chromatin
Subjects:
X-chromosome inactivation
Xist
Noncoding RNA
MeCP2
Rett syndrome
Online Access:http://link.springer.com/article/10.1186/s13072-018-0219-8

Internet

http://link.springer.com/article/10.1186/s13072-018-0219-8

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