Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients

Targeting Tyrosine Phosphatases by 3-Bromopyruvate Overcomes Hyperactivation of Platelets from Gastrointestinal Cancer Patients

Venous thromboembolism (VTE) is one of the most common causes of cancer related mortality. It has been speculated that hypercoagulation in cancer patients is triggered by direct or indirect contact of platelets with tumor cells, however the underlying molecular mechanisms involved are currently unkn...

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Bibliographic Details
Main Authors: Alessandra V. S. Faria, Sheila S. Andrade, Agnes N. Reijm, Manon C. W. Spaander, Moniek P. M. de Maat, Maikel P. Peppelenbosch, Carmen V. Ferreira-Halder, Gwenny M. Fuhler
Format: Article
Language:English
Published: MDPI AG 2019-06-01
Series:Journal of Clinical Medicine
Subjects:
platelet function
gastrointestinal cancer
venous thromboembolism
tyrosine phosphatases
LMWPTP
ACP1
PTP1B
Online Access:https://www.mdpi.com/2077-0383/8/7/936

Internet

https://www.mdpi.com/2077-0383/8/7/936

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