Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons

Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons

Abstract Background The inability to analyze gene expression in living neurons from Angelman (AS) and Duplication 15q (Dup15q) syndrome subjects has limited our understanding of these disorders at the molecular level. Method Here, we use dental pulp stem cells (DPSC) from AS deletion, 15q Duplicatio...

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Bibliographic Details
Main Authors: Nora Urraca, Kevin Hope, A. Kaitlyn Victor, T. Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh T. Tran, Silvia Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges, Lawrence T. Reiter
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Autism
Subjects:
Stem cells
Autism
Genomic disorders
Neurogenetic syndrome
mRNAseq
Online Access:http://link.springer.com/article/10.1186/s13229-018-0191-y

Internet

http://link.springer.com/article/10.1186/s13229-018-0191-y

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