Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.

Structure-based prediction of asparagine and aspartate degradation sites in antibody variable regions.

Monoclonal antibodies (mAbs) and proteins containing antibody domains are the most prevalent class of biotherapeutics in diverse indication areas. Today, established techniques such as immunization or phage display allow for an efficient generation of new mAbs. Besides functional properties, the sta...

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Bibliographic Details
Main Authors: Jasmin F Sydow, Florian Lipsmeier, Vincent Larraillet, Maximiliane Hilger, Bjoern Mautz, Michael Mølhøj, Jan Kuentzer, Stefan Klostermann, Juergen Schoch, Hans R Voelger, Joerg T Regula, Patrick Cramer, Apollon Papadimitriou, Hubert Kettenberger
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4069079?pdf=render

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http://europepmc.org/articles/PMC4069079?pdf=render

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