Rheumatoid Synovial Fluids Regulate the Immunomodulatory Potential of Adipose-Derived Mesenchymal Stem Cells Through a TNF/NF-κB-Dependent Mechanism

Rheumatoid Synovial Fluids Regulate the Immunomodulatory Potential of Adipose-Derived Mesenchymal Stem Cells Through a TNF/NF-κB-Dependent Mechanism

Introduction: Adipose-derived mesenchymal stem cells (ADSC) have been shown to have remarkable immune-modulating effects. However, their efficacy in clinical trials has yet to be fully demonstrated. This could be due to a lack of a proper inflammatory environment in vivo that primes ADSC. Here, we d...

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Bibliographic Details
Main Authors: Souraya Sayegh, Oula El Atat, Katy Diallo, Benjamin Rauwel, Yannick Degboé, Etienne Cavaignac, Arnaud Constantin, Alain Cantagrel, Viviane Trak-Smayra, Nada Alaaeddine, Jean-Luc Davignon
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
mesenchymal stem cells
rheumatoid arthritis
synovial fluid
immunomodulation
TNF
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01482/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01482/full

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