The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs

The ROS/SUMO Axis Contributes to the Response of Acute Myeloid Leukemia Cells to Chemotherapeutic Drugs

Chemotherapeutic drugs used in the treatment of acute myeloid leukemias (AMLs) are thought to induce cancer cell death through the generation of DNA double-strand breaks. Here, we report that one of their early effects is the loss of conjugation of the ubiquitin-like protein SUMO from its targets vi...

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Bibliographic Details
Main Authors: Guillaume Bossis, Jean-Emmanuel Sarry, Chamseddine Kifagi, Marko Ristic, Estelle Saland, François Vergez, Tamara Salem, Héléna Boutzen, Hayeon Baik, Frédérique Brockly, Mireia Pelegrin, Tony Kaoma, Laurent Vallar, Christian Récher, Stéphane Manenti, Marc Piechaczyk
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S221112471400391X

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http://www.sciencedirect.com/science/article/pii/S221112471400391X

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