Characterization of Hematopoiesis in Sickle Cell Disease by Prospective Isolation of Stem and Progenitor Cells

Characterization of Hematopoiesis in Sickle Cell Disease by Prospective Isolation of Stem and Progenitor Cells

The consequences of sickle cell disease (SCD) include ongoing hematopoietic stress, hemolysis, vascular damage, and effect of chronic therapies, such as blood transfusions and hydroxyurea, on hematopoietic stem and progenitor cell (HSPC) have been poorly characterized. We have quantified the frequen...

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Bibliographic Details
Main Authors: Seda S. Tolu, Kai Wang, Zi Yan, Shouping Zhang, Karl Roberts, Andrew S. Crouch, Gracy Sebastian, Mark Chaitowitz, Eric D. Fornari, Evan M. Schwechter, Joan Uehlinger, Deepa Manwani, Caterina P. Minniti, Eric E. Bouhassira
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Cells
Subjects:
sickle cell disease
hematopoietic stem cells
hydroxyurea
transfusion
Online Access:https://www.mdpi.com/2073-4409/9/10/2159

Internet

https://www.mdpi.com/2073-4409/9/10/2159

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