Viral hijacking of a replicative helicase loader and its implications for helicase loading control and phage replication

Replisome assembly requires the loading of replicative hexameric helicases onto origins by AAA+ ATPases. How loader activity is appropriately controlled remains unclear. Here, we use structural and biochemical analyses to establish how an antimicrobial phage protein interferes with the function of t...

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Bibliographic Details
Main Authors: Iris V Hood, James M Berger
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/14158