Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines

Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines

Therapeutic agents used in the treatment of cancer are known to develop resistance against cancer cells. Hence, there is a continuing need to investigate novel agents for the treatment and management of cancer. Antitumor activity of greensporone C (GC), a new resorcylic acid lactone isolated from an...

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Bibliographic Details
Main Authors: Kirti S. Prabhu, Kodappully Sivaraman Siveen, Shilpa Kuttikrishnan, Ahmad N. Iskandarani, Abdul Q. Khan, Maysaloun Merhi, Halima E. Omri, Said Dermime, Tamam El-Elimat, Nicholas H. Oberlies, Feras Q. Alali, Shahab Uddin
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
AKT
apoptosis
greensporone C
leukemia
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00720/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00720/full

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