WWOX Possesses <i>N</i>-Terminal Cell Surface-Exposed Epitopes WWOX<sub>7-21</sub> and WWOX<sub>7-11</sub> for Signaling Cancer Growth Suppression and Prevention In Vivo

WWOX Possesses <i>N</i>-Terminal Cell Surface-Exposed Epitopes WWOX<sub>7-21</sub> and WWOX<sub>7-11</sub> for Signaling Cancer Growth Suppression and Prevention In Vivo

Membrane hyaluronidase Hyal-2 supports cancer cell growth. Inhibition of Hyal-2 by specific antibody against Hyal-2 or pY216-Hyal-2 leads to cancer growth suppression and prevention in vivo. By immunoelectron microscopy, tumor suppressor WWOX is shown to be anchored, in part, in the cell membrane by...

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Bibliographic Details
Main Authors: Wan-Jen Wang, Pei-Chuan Ho, Ganesan Nagarajan, Yu-An Chen, Hsiang-Ling Kuo, Dudekula Subhan, Wan-Pei Su, Jean-Yun Chang, Chen-Yu Lu, Katarina T. Chang, Sing-Ru Lin, Ming-Hui Lee, Nan-Shan Chang
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cancers
Subjects:
tumor suppressor
wwox
epitopes
peptides
phosphorylation
stem cell spheres
zfra
time-lapse microscopy
Online Access:https://www.mdpi.com/2072-6694/11/11/1818

Internet

https://www.mdpi.com/2072-6694/11/11/1818

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