Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4−/−Gpihbp1−/− mice

Novel GPIHBP1-independent pathway for clearance of plasma TGs in Angptl4−/−Gpihbp1−/− mice

Mice lacking glycosylphosphatidylinositol-anchored HDL-binding protein 1 (GPIHBP1) are unable to traffic LPL to the vascular lumen. Thus, triglyceride (TG) clearance is severely blunted, and mice are extremely hypertriglyceridemic. Paradoxically, mice lacking both GPIHBP1 and the LPL regulator, angi...

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Bibliographic Details
Main Authors: Emily M. Cushing, Kelli L. Sylvers, Xun Chi, Shwetha K. Shetty, BrandonS.J. Davies
Format: Article
Language:English
Published: Elsevier 2018-01-01
Series:Journal of Lipid Research
Subjects:
lipoprotein metabolism
lipolysis and fatty acid metabolism
lipase inhibition
adipose tissue
chylomicrons
lipoprotein lipase
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520330807

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http://www.sciencedirect.com/science/article/pii/S0022227520330807

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