A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts.

A Molecular Host Response Assay to Discriminate Between Sepsis and Infection-Negative Systemic Inflammation in Critically Ill Patients: Discovery and Validation in Independent Cohorts.

Systemic inflammation is a whole body reaction having an infection-positive (i.e., sepsis) or infection-negative origin. It is important to distinguish between these two etiologies early and accurately because this has significant therapeutic implications for critically ill patients. We hypothesized...

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Bibliographic Details
Main Authors: Leo McHugh, Therese A Seldon, Roslyn A Brandon, James T Kirk, Antony Rapisarda, Allison J Sutherland, Jeffrey J Presneill, Deon J Venter, Jeffrey Lipman, Mervyn R Thomas, Peter M C Klein Klouwenberg, Lonneke van Vught, Brendon Scicluna, Marc Bonten, Olaf L Cremer, Marcus J Schultz, Tom van der Poll, Thomas D Yager, Richard B Brandon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-12-01
Series:PLoS Medicine
Online Access:http://europepmc.org/articles/PMC4672921?pdf=render

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http://europepmc.org/articles/PMC4672921?pdf=render

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