Inhibition of Human Transthyretin Aggregation by Non-Steroidal Anti-Inflammatory Compounds: A Structural and Thermodynamic Analysis

Inhibition of Human Transthyretin Aggregation by Non-Steroidal Anti-Inflammatory Compounds: A Structural and Thermodynamic Analysis

Transthyretin (TTR) is a homotetrameric protein that circulates in plasma and cerebral spinal fluid (CSF) whose aggregation into amyloid fibrils has been associated with at least two different amyloid diseases: senile systemic amyloidosis (SSA) and familial amyloid polyneuropathy (FAP). In SSA aggre...

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Bibliographic Details
Main Authors: Luis Mauricio T. R. Lima, Debora Foguel, Salvador Ventura, Ricardo O. Sant'Anna, Carolina A. Braga, Igor Polikarpov
Format: Article
Language:English
Published: MDPI AG 2013-03-01
Series:International Journal of Molecular Sciences
Subjects:
transthyretin
protein aggregation
high hydrostatic pressure
crystallography
inhibitors
Online Access:http://www.mdpi.com/1422-0067/14/3/5284

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http://www.mdpi.com/1422-0067/14/3/5284

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