Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation

Functional Characterization of Rare Variants in the SHOX2 Gene Identified in Sinus Node Dysfunction and Atrial Fibrillation

Sinus node dysfunction (SND) and atrial fibrillation (AF) often coexist; however, the molecular mechanisms linking both conditions remain elusive. Mutations in the homeobox-containing SHOX2 gene have been recently associated with early-onset and familial AF. Shox2 is a key regulator of sinus node de...

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Bibliographic Details
Main Authors: Sandra Hoffmann, Christoph Paone, Simon A. Sumer, Sabrina Diebold, Birgit Weiss, Ralph Roeth, Sebastian Clauss, Ina Klier, Stefan Kääb, Andreas Schulz, Philipp S. Wild, Adil Ghrib, Tanja Zeller, Renate B. Schnabel, Steffen Just, Gudrun A. Rappold
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Genetics
Subjects:
Shox2
transcription factor
cardiac conduction system
pacemaker
arrhythmias
atrial fibrillation
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00648/full

Internet

https://www.frontiersin.org/article/10.3389/fgene.2019.00648/full

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