Cyclosporine A induces apoptotic and autophagic cell death in rat pituitary GH3 cells.

Cyclosporine A (CsA) is a powerful immunosuppressive drug with side effects including the development of chronic nephrotoxicity. In this study, we investigated CsA treatment induced apoptotic and autophagic cell death in pituitary GH3 cells. CsA treatment (0.1 to 10 µM) decreased survival of GH3 cel...

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Bibliographic Details
Main Authors: Han Sung Kim, Seung-Il Choi, Eui-Bae Jeung, Yeong-Min Yoo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4191984?pdf=render