Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo

Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo

Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder characterized by the loss of motor neurons in the central nervous system, has no known cure to-date. Disease causing mutations in human Fused in Sarcoma (FUS) leads to aggressive and juvenile onset of ALS. FUS is a well-con...

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Bibliographic Details
Main Authors: Neha Gogia, Ankita Sarkar, Abijeet Singh Mehta, Ph.D., Nandini Ramesh, Prajakta Deshpande, Madhuri Kango-Singh, Udai Bhan Pandey, Amit Singh
Format: Article
Language:English
Published: Elsevier 2020-07-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Amyotrophic Lateral Sclerosis (ALS)
Fused in Sarcoma (FUS)
Translocated in Liposarcoma (TLS)
Drosophila eye
Hippo pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996120301121

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http://www.sciencedirect.com/science/article/pii/S0969996120301121

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