Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction

Inhibition of KCa2 and Kv11.1 Channels in Pigs With Left Ventricular Dysfunction

BackgroundInhibition of KCa2 channels, conducting IKCa, can convert atrial fibrillation (AF) to sinus rhythm and protect against its induction. IKCa inhibition has been shown to possess functional atrial selectivity with minor effects on ventricles. Under pathophysiological conditions with ventricul...

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Bibliographic Details
Main Authors: Carlotta Citerni, Jeppe Kirchhoff, Lisbeth Høier Olsen, Stefan Michael Sattler, Morten Grunnet, Nils Edvardsson, Bo Hjorth Bentzen, Jonas Goldin Diness
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
ventricular dysfunction
KCa2 channels
small-conductance Ca2+-activated K+ channels
atrial fibrillation
pig model
dofetilide
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00556/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.00556/full

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