Eltrombopag Improves Erythroid Differentiation in a Human Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia

Eltrombopag Improves Erythroid Differentiation in a Human Induced Pluripotent Stem Cell Model of Diamond Blackfan Anemia

Diamond Blackfan Anemia (DBA) is a congenital macrocytic anemia associated with ribosomal protein haploinsufficiency. Ribosomal dysfunction delays globin synthesis, resulting in excess toxic free heme in erythroid progenitors, early differentiation arrest, and pure red cell aplasia. In this study, D...

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Bibliographic Details
Main Authors: Husam Qanash, Yongqin Li, Richard H. Smith, Kaari Linask, Sara Young-Baird, Waleed Hakami, Keyvan Keyvanfar, John S. Choy, Jizhong Zou, Andre Larochelle
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cells
Subjects:
diamond blackfan anemia
induced pluripotent stem cells
eltrombopag
genome editing
disease modeling
drug testing
Online Access:https://www.mdpi.com/2073-4409/10/4/734

Internet

https://www.mdpi.com/2073-4409/10/4/734

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