Hypoxia-Induced Alpha-Globin Expression in Syncytiotrophoblasts Mimics the Pattern Observed in Preeclamptic Placentas

Hypoxia-Induced Alpha-Globin Expression in Syncytiotrophoblasts Mimics the Pattern Observed in Preeclamptic Placentas

Preeclampsia (PE) is a pregnancy disorder associated with placental dysfunction and elevated fetal hemoglobin (HbF). Early in pregnancy the placenta harbors hematopoietic stem and progenitor cells (HSPCs) and is an extramedullary source of erythropoiesis. However, globin expression is not unique to...

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Bibliographic Details
Main Authors: Zahra Masoumi, Lena Erlandsson, Eva Hansson, Mattias Magnusson, Eva Mezey, Stefan R. Hansson
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
preeclampsia
placenta
erythropoiesis
oxidative stress
non-erythroid globin
syncytiotrophoblast
Online Access:https://www.mdpi.com/1422-0067/22/7/3357

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https://www.mdpi.com/1422-0067/22/7/3357

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