Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-alpha induction.

Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-alpha induction.

Highly pathogenic avian influenza virus (HPAIV) of the subtype H5N1 causes severe, often fatal pneumonia in humans. The pathogenesis of HPAIV H5N1 infection is not completely understood, although the alveolar macrophage (AM) is thought to play an important role. HPAIV H5N1 infection of macrophages c...

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Bibliographic Details
Main Authors: Debby van Riel, Lonneke M E Leijten, Menno van der Eerden, Henk C Hoogsteden, Leonie A Boven, Bart N Lambrecht, Albert D M E Osterhaus, Thijs Kuiken
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-06-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3121882?pdf=render

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http://europepmc.org/articles/PMC3121882?pdf=render

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