Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion

Retinal ischemia induces α-SMA-mediated capillary pericyte contraction coincident with perivascular glycogen depletion

Abstract Increasing evidence indicates that pericytes are vulnerable cells, playing pathophysiological roles in various neurodegenerative processes. Microvascular pericytes contract during cerebral and coronary ischemia and do not relax after re-opening of the occluded artery, causing incomplete rep...

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Bibliographic Details
Main Authors: Luis Alarcon-Martinez, Sinem Yilmaz-Ozcan, Muge Yemisci, Jesse Schallek, Kıvılcım Kılıç, Deborah Villafranca-Baughman, Alp Can, Adriana Di Polo, Turgay Dalkara
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Acta Neuropathologica Communications
Subjects:
Retinal ischemia/reperfusion
Retinal pericytes
Capillary constriction
Retinal vasculature
Alpha-smooth muscle actin
Online Access:http://link.springer.com/article/10.1186/s40478-019-0761-z

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http://link.springer.com/article/10.1186/s40478-019-0761-z

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