α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy

α-Methyl-α-phenylsuccinimide ameliorates neurodegeneration in a C. elegans model of TDP-43 proteinopathy

The antiepileptic drug ethosuximide has recently been shown to be neuroprotective in various Caenorhabditis elegans and rodent neurodegeneration models. It is therefore a promising repurposing candidate for the treatment of multiple neurodegenerative diseases. However, high concentrations of the dru...

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Bibliographic Details
Main Authors: Shi Quan Wong, Matthew G. Pontifex, Marie M. Phelan, Chandra Pidathala, Brian C. Kraemer, Jeff W. Barclay, Neil G. Berry, Paul M. O'Neill, Robert D. Burgoyne, Alan Morgan
Format: Article
Language:English
Published: Elsevier 2018-10-01
Series:Neurobiology of Disease
Subjects:
Neurodegeneration
Amyotrophic lateral sclerosis
Frontotemporal lobar degeneration
Ethosuximide
Methsuximide
Desmethylmethsuximide
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611830192X

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http://www.sciencedirect.com/science/article/pii/S096999611830192X

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