Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells

Dock10, a Cdc42 and Rac1 GEF, induces loss of elongation, filopodia, and ruffles in cervical cancer epithelial HeLa cells

Dock10 is one of the three members of the Dock-D family of Dock proteins, a class of guanine nucleotide exchange factors (GEFs) for Rho GTPases. Its homologs Dock9 and Dock11 are Cdc42 GEFs. Dock10 is required for maintenance of rounded morphology and amoeboid-type movement. Full-length isoforms of...

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Bibliographic Details
Main Authors: Natalia Ruiz-Lafuente, María-José Alcaraz-García, Azahara-María García-Serna, Silvia Sebastián-Ruiz, María-Rosa Moya-Quiles, Ana-María García-Alonso, Antonio Parrado
Format: Article
Language:English
Published: The Company of Biologists 2015-07-01
Series:Biology Open
Subjects:
Dock10
Dock9
Dock11
Cdc42
Rac1
filopodia
membrane ruffles
Online Access:http://bio.biologists.org/content/4/5/627

Internet

http://bio.biologists.org/content/4/5/627

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