Slit1 Protein Regulates SVZ-Derived Precursor Mobilization in the Adult Demyelinated CNS

Slit1 Protein Regulates SVZ-Derived Precursor Mobilization in the Adult Demyelinated CNS

Slit1 is a secreted axon guidance molecule, also involved in adult neurogenesis. In physiological conditions, Slit1 loss promotes ectopic dispersal of SVZ-derived neural precursors (SVZ-NPCs) into periventricular structures such as the corpus callosum. Demyelination of the corpus callosum triggers S...

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Bibliographic Details
Main Authors: C. Deboux, G. Spigoni, C. Caillava, B. Garcia-Diaz, A. Ypsilanti, N. Sarrazin, C. Bachelin, A. Chédotal, A. Baron-Van Evercooren
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Slit1
neural precursor
oligodendrocytes
recruitment
migration
myelin
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2020.00168/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2020.00168/full

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