3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis

3,3′-Diindolylmethane Suppresses the Growth of Hepatocellular Carcinoma by Regulating Its Invasion, Migration, and ER Stress-Mediated Mitochondrial Apoptosis

Hepatocellular carcinoma (HCC) is the leading cause of cancer-related death worldwide with limited treatment options. Biomarker-based active phenolic flavonoids isolated from medicinal plants might shed some light on potential therapeutics for treating HCC. 3,3′-diindolylmethane (DIM) is a unique bi...

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Bibliographic Details
Main Authors: Suvesh Munakarmi, Juna Shrestha, Hyun-Beak Shin, Geum-Hwa Lee, Yeon-Jun Jeong
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cells
Subjects:
ER stress
unfolded protein response
hepatocellular carcinoma
apoptosis
EMT
DIM
Online Access:https://www.mdpi.com/2073-4409/10/5/1178

Internet

https://www.mdpi.com/2073-4409/10/5/1178

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