Validity of Quinpirole Sensitization Rat Model of OCD: Linking Evidence from Animal and Clinical Studies

Validity of Quinpirole Sensitization Rat Model of OCD: Linking Evidence from Animal and Clinical Studies

Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder with 1-3% prevalence. OCD is characterized by recurrent thoughts (obsessions) and repetitive behaviors (compulsions). The pathophysiology of OCD remains unclear, stressing the importance of pre-clinical studies. The aim of this artic...

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Bibliographic Details
Main Authors: Ales Stuchlik, Dominika Radostová, Hana Hatalova, Karel Vales, Tereza Nekovarova, Jana Koprivova, Jan Svoboda, Jiri Horacek
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Quinpirole
human
rat
animal model
OCD
brain circuits
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00209/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnbeh.2016.00209/full

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