Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis

Epithelial and interstitial Notch1 activity contributes to the myofibroblastic phenotype and fibrosis

Abstract Background Notch1 signalling is a stem-cell-related pathway that is essential for embryonic development, tissue regeneration and organogenesis. However, the role of Notch1 in the formation of myofibroblasts and fibrosis in kidneys following injury remains unknown. Methods The activity of No...

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Bibliographic Details
Main Authors: Weilong Hong, Ge Zhang, Hong Lu, Yangyang Guo, Shizhang Zheng, Hengyue Zhu, Yanyi Xiao, Akuetteh Percy David Papa, Cunzao Wu, Linxiao Sun, Bicheng Chen, Yongheng Bai
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cell Communication and Signaling
Subjects:
Notch1 signalling
Myofibroblastic phenotype
Epithelial-mesenchymal transition (EMT)
Fibroblast-myofibroblast differentiation (FMD)
Renal fibrosis
Online Access:http://link.springer.com/article/10.1186/s12964-019-0455-y

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http://link.springer.com/article/10.1186/s12964-019-0455-y

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