Epistatic interaction between the lipase-encoding genes Pnpla2 and Lipe causes liposarcoma in mice.

Liposarcoma is an often fatal cancer of fat cells. Mechanisms of liposarcoma development are incompletely understood. The cleavage of fatty acids from acylglycerols (lipolysis) has been implicated in cancer. We generated mice with adipose tissue deficiency of two major enzymes of lipolysis, adipose...

Full description

Bibliographic Details
Main Authors: Jiang Wei Wu, Christoph Preuss, Shu Pei Wang, Hao Yang, Bo Ji, Gregory W Carter, Rebecca Gladdy, Gregor Andelfinger, Grant A Mitchell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-05-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5432192?pdf=render