Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type

Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type

Abstract Background The lifelong accumulation of somatic mutations underlies age-related phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in a tissue-specific way. Whole genome analyses of somatic mutation patterns, based on both types and genomic distribution o...

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Bibliographic Details
Main Authors: Irene Franco, Hafdis T. Helgadottir, Aldo Moggio, Malin Larsson, Peter Vrtačnik, Anna Johansson, Nina Norgren, Pär Lundin, David Mas-Ponte, Johan Nordström, Torbjörn Lundgren, Peter Stenvinkel, Lars Wennberg, Fran Supek, Maria Eriksson
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Genome Biology
Subjects:
Somatic mutations
Aging
Kidney cancer
Proximal tubule
kidney progenitors
Online Access:https://doi.org/10.1186/s13059-019-1892-z

Internet

https://doi.org/10.1186/s13059-019-1892-z

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