Whole genome DNA sequencing provides an atlas of somatic mutagenesis in healthy human cells and identifies a tumor-prone cell type
Abstract Background The lifelong accumulation of somatic mutations underlies age-related phenotypes and cancer. Mutagenic forces are thought to shape the genome of aging cells in a tissue-specific way. Whole genome analyses of somatic mutation patterns, based on both types and genomic distribution o...
Main Authors: | Irene Franco, Hafdis T. Helgadottir, Aldo Moggio, Malin Larsson, Peter Vrtačnik, Anna Johansson, Nina Norgren, Pär Lundin, David Mas-Ponte, Johan Nordström, Torbjörn Lundgren, Peter Stenvinkel, Lars Wennberg, Fran Supek, Maria Eriksson |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2019-12-01
|
Series: | Genome Biology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13059-019-1892-z |
Similar Items
-
Morfometría de cortes histológicos de los túbulos renales normales en una muestra de humanos adultos
by: Miosotis de Lourdes Fernández Lastre, et al.
Published: (2017-01-01) -
PROXIMAL TUBULE SUSPENSIONS FROM RABBIT KIDNEY: AN IN VITRO SYSTEM FOR THE STUDY OF NEPHROTOXICITY.
by: RYLANDER, LESLIE ANN.
Published: (1986) -
Suggestions for attenuation of renal ischemia reperfusion injury based on mechanisms involved in epithelial cells damages
by: Tavafi Majid
Published: (2015-01-01) -
An abundant quiescent stem cell population in Drosophila Malpighian tubules protects principal cells from kidney stones
by: Chenhui Wang, et al.
Published: (2020-03-01) -
MECHANISMS UNDERLYING REGIOSELECTIVE ACUTE TUBULAR NECROSIS OF RENAL PROXIMAL TUBULAR SEGMENTS.
by: RUEGG, CHARLES EDWARD.
Published: (1987)