Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding

Embryonic Program Activated during Blast Crisis of Chronic Myelogenous Leukemia (CML) Implicates a TCF7L2 and MYC Cooperative Chromatin Binding

Chronic myeloid leukemia (CML) is characterized by an inherent genetic instability, which contributes to the progression of the disease towards an accelerated phase (AP) and blast crisis (BC). Several cytogenetic and genomic alterations have been reported in the progression towards BC, but the preci...

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Bibliographic Details
Main Authors: Christophe Desterke, Patricia Hugues, Jin Wook Hwang, Annelise Bennaceur-Griscelli, Ali G. Turhan
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:International Journal of Molecular Sciences
Subjects:
chronic myelogenous leukemia
epigenetics
blast crisis
MYC
TCF7L2
leukemic stem cells
Online Access:https://www.mdpi.com/1422-0067/21/11/4057

Internet

https://www.mdpi.com/1422-0067/21/11/4057

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