Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARγ Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFα/Survivin Pathway

Protective Effects of Irbesartan, an Angiotensin Receptor Blocker with PPARγ Agonistic Activity, against Estradiol Benzoate-Induced Endometrial Hyperplasia and Atypia in Female Rats via Modulation of TNFα/Survivin Pathway

Endometrial hyperplasia (EH) is a common gynecological problem and may progress to carcinoma. Early detection and management of EH are mandatory for the prevention of endometrial cancer. Activation of the renin–angiotensin system and angiotensin II signaling are involved in the progression of precan...

Full description

Bibliographic Details
Main Authors: Mohamed A. Morsy, Wedad M. Abdelraheem, Maram El-Hussieny, Marwa M. M. Refaie
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
endometrial hyperplasia
irbesartan
estradiol benzoate
tumor necrosis factor-alpha
survivin
cleaved caspase 3
Online Access:https://www.mdpi.com/1424-8247/14/7/649

Internet

https://www.mdpi.com/1424-8247/14/7/649

Similar Items