Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system

Transition from enhanced T cell infiltration to inflammation in the myelin-degenerative central nervous system

Myelin degeneration in the central nervous system (CNS) is often associated with elevated numbers of T cells in brain and spinal cord (SC). In some degenerative diseases, this T cell immigration has no clinical relevance, in others, it may precede severe inflammation and tissue damage. We studied T...

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Bibliographic Details
Main Authors: Roland Grundtner, Klaus Dornmair, Ralf Dahm, Alexander Flügel, Naoto Kawakami, Manuel Zeitelhofer, Lucia Schoderboeck, Mikhail Nosov, Edgar Selzer, Martin Willheim, Michael Kiebler, Hartmut Wekerle, Hans Lassmann, Monika Bradl
Format: Article
Language:English
Published: Elsevier 2007-12-01
Series:Neurobiology of Disease
Subjects:
CDR3 spectratyping
T cells
Myelin degeneration
Inflammation
Motility
Microglia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107001659

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http://www.sciencedirect.com/science/article/pii/S0969996107001659

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