Beta‐cell excitability and excitability‐driven diabetes in adult Zebrafish islets

Beta‐cell excitability and excitability‐driven diabetes in adult Zebrafish islets

Abstract Islet β‐cell membrane excitability is a well‐established regulator of mammalian insulin secretion, and defects in β‐cell excitability are linked to multiple forms of diabetes. Evolutionary conservation of islet excitability in lower organisms is largely unexplored. Here we show that adult z...

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Bibliographic Details
Main Authors: Christopher H. Emfinger, Réka Lőrincz, Yixi Wang, Nathaniel W. York, Soma S. Singareddy, Jennifer M. Ikle, Robert C. Tryon, Conor McClenaghan, Zeenat A. Shyr, Yan Huang, Christopher A. Reissaus, Dirk Meyer, David W. Piston, Krzysztof Hyrc, Maria S. Remedi, Colin G. Nichols
Format: Article
Language:English
Published: Wiley 2019-06-01
Series:Physiological Reports
Subjects:
Calcium channels
insulin secretion
KATP
metabolism
pancreas
zebrafish
Online Access:https://doi.org/10.14814/phy2.14101

Internet

https://doi.org/10.14814/phy2.14101

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