PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein

PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein

Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby impl...

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Main Authors: Min Thura, Abdul Qader Al-Aidaroos, Abhishek Gupta, Cheng Ean Chee, Soo Chin Lee, Kam Man Hui, Jie Li, Yeoh Khay Guan, Wei Peng Yong, Jimmy So, Wee Joo Chng, Chin Hin Ng, Jianbiao Zhou, Ling Zhi Wang, John Shyi Peng Yuen, Henry Sun Sien Ho, Sim Mei Yi, Edmund Chiong, Su Pin Choo, Joanne Ngeow, Matthew Chau Hsien Ng, Clarinda Chua, Eugene Shen Ann Yeo, Iain Bee Huat Tan, Joel Xuan En Sng, Nicholas Yan Zhi Tan, Jean Paul Thiery, Boon Cher Goh, Qi Zeng
Format: Article
Language:English
Published: Nature Publishing Group 2019-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10127-x
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spelling doaj-a0d6749bcea14e23bb0de1ac495322d32021-05-11T12:06:18ZengNature Publishing GroupNature Communications2041-17232019-06-0110111410.1038/s41467-019-10127-xPRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoproteinMin Thura0Abdul Qader Al-Aidaroos1Abhishek Gupta2Cheng Ean Chee3Soo Chin Lee4Kam Man Hui5Jie Li6Yeoh Khay Guan7Wei Peng Yong8Jimmy So9Wee Joo Chng10Chin Hin Ng11Jianbiao Zhou12Ling Zhi Wang13John Shyi Peng Yuen14Henry Sun Sien Ho15Sim Mei Yi16Edmund Chiong17Su Pin Choo18Joanne Ngeow19Matthew Chau Hsien Ng20Clarinda Chua21Eugene Shen Ann Yeo22Iain Bee Huat Tan23Joel Xuan En Sng24Nicholas Yan Zhi Tan25Jean Paul Thiery26Boon Cher Goh27Qi Zeng28Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS)Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS)Division of Cellular and Molecular Research, National Cancer Centre SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Department of Medicine, Yong Loo Lin School of Medicine, National University of SingaporeDepartment of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS)Division of Surgical Oncology, National University Cancer Institute, Singapore (NCIS)Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS)Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS)Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS)Cancer Science Institute of Singapore, National University of SingaporeDepartment of Urology, Singapore General HospitalDepartment of Urology, Singapore General HospitalDepartment of Urology, Singapore General HospitalDivision of Surgical Oncology, National University Cancer Institute, Singapore (NCIS)Division of Medical Oncology, National Cancer Centre SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Division of Medical Oncology, National Cancer Centre SingaporeDivision of Medical Oncology, National Cancer Centre SingaporeDepartment of Colorectal Surgery, Singapore General HospitalDivision of Medical Oncology, National Cancer Centre SingaporeInstitute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Department of Haematology-Oncology, National University Cancer Institute, Singapore (NCIS)Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR)Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.https://doi.org/10.1038/s41467-019-10127-x
collection DOAJ
language English
format Article
sources DOAJ
author Min Thura
Abdul Qader Al-Aidaroos
Abhishek Gupta
Cheng Ean Chee
Soo Chin Lee
Kam Man Hui
Jie Li
Yeoh Khay Guan
Wei Peng Yong
Jimmy So
Wee Joo Chng
Chin Hin Ng
Jianbiao Zhou
Ling Zhi Wang
John Shyi Peng Yuen
Henry Sun Sien Ho
Sim Mei Yi
Edmund Chiong
Su Pin Choo
Joanne Ngeow
Matthew Chau Hsien Ng
Clarinda Chua
Eugene Shen Ann Yeo
Iain Bee Huat Tan
Joel Xuan En Sng
Nicholas Yan Zhi Tan
Jean Paul Thiery
Boon Cher Goh
Qi Zeng
spellingShingle Min Thura
Abdul Qader Al-Aidaroos
Abhishek Gupta
Cheng Ean Chee
Soo Chin Lee
Kam Man Hui
Jie Li
Yeoh Khay Guan
Wei Peng Yong
Jimmy So
Wee Joo Chng
Chin Hin Ng
Jianbiao Zhou
Ling Zhi Wang
John Shyi Peng Yuen
Henry Sun Sien Ho
Sim Mei Yi
Edmund Chiong
Su Pin Choo
Joanne Ngeow
Matthew Chau Hsien Ng
Clarinda Chua
Eugene Shen Ann Yeo
Iain Bee Huat Tan
Joel Xuan En Sng
Nicholas Yan Zhi Tan
Jean Paul Thiery
Boon Cher Goh
Qi Zeng
PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
Nature Communications
author_facet Min Thura
Abdul Qader Al-Aidaroos
Abhishek Gupta
Cheng Ean Chee
Soo Chin Lee
Kam Man Hui
Jie Li
Yeoh Khay Guan
Wei Peng Yong
Jimmy So
Wee Joo Chng
Chin Hin Ng
Jianbiao Zhou
Ling Zhi Wang
John Shyi Peng Yuen
Henry Sun Sien Ho
Sim Mei Yi
Edmund Chiong
Su Pin Choo
Joanne Ngeow
Matthew Chau Hsien Ng
Clarinda Chua
Eugene Shen Ann Yeo
Iain Bee Huat Tan
Joel Xuan En Sng
Nicholas Yan Zhi Tan
Jean Paul Thiery
Boon Cher Goh
Qi Zeng
author_sort Min Thura
title PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_short PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_full PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_fullStr PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_full_unstemmed PRL3-zumab as an immunotherapy to inhibit tumors expressing PRL3 oncoprotein
title_sort prl3-zumab as an immunotherapy to inhibit tumors expressing prl3 oncoprotein
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-06-01
description Phosphatase of regenerating liver 3 (PRL3) is usually found intracellularly, and is over-expressed in cancer cells. Here the authors show that PRL-3 is also detectable on cell surface, and can be recognized by PRL3-zumab to recruit immune cells into tumor to promote anti-tumor immunity, thereby implicating PRL-3 as a potential tumor antigen.
url https://doi.org/10.1038/s41467-019-10127-x
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