Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

The molecular mechanisms underlying vascular inflammation are unclear. Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in...

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Bibliographic Details
Main Authors: Yiming Xu, Yong Wang, Siyuan Yan, Qiuhua Yang, Yaqi Zhou, Xianqiu Zeng, Zhiping Liu, Xiaofei An, Haroldo A. Toque, Zheng Dong, Xuejun Jiang, David J. Fulton, Neal L. Weintraub, Qinkai Li, Zsolt Bagi, Mei Hong, Detlev Boison, Chaodong Wu, Yuqing Huo
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00986-7

Internet

https://doi.org/10.1038/s41467-017-00986-7

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