A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy

C-to-U RNA editing of glycine receptors (GlyR) can play an important role in disease progression of temporal lobe epilepsy (TLE) as it may contribute in a neuron type-specific way to neuropsychiatric symptoms of the disease. It is therefore necessary to develop tools that allow identification of neu...

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Bibliographic Details
Main Authors: Svenja Kankowski, Benjamin Förstera, Aline Winkelmann, Pina Knauff, Erich E. Wanker, Xintian A. You, Marcus Semtner, Florian Hetsch, Jochen C. Meier
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
glycine receptors
epilepsy
temporal lobe
RNA editing
hippocampus
ligands
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2017.00439/full

Internet

https://www.frontiersin.org/article/10.3389/fnmol.2017.00439/full

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