Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion.

Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion.

Several studies indicate that the activity of cruzipain, the main lysosomal cysteine peptidase of Trypanosoma cruzi, contributes to parasite infectivity. In addition, the parasitic invasion process of mammalian host cells is described to be dependent on the activation of the host TGF-β signaling pat...

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Bibliographic Details
Main Authors: Patrícia Mello Ferrão, Claudia Masini d'Avila-Levy, Tania Cremonini Araujo-Jorge, Wim Maurits Degrave, Antônio da Silva Gonçalves, Luciana Ribeiro Garzoni, Ana Paula Lima, Jean Jacques Feige, Sabine Bailly, Leila Mendonça-Lima, Mariana Caldas Waghabi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4418758?pdf=render

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http://europepmc.org/articles/PMC4418758?pdf=render

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