PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.

Bibliographic Details
Main Authors: Tao Chen, Jingjie Li, Meidong Xu, Qin Zhao, Yingyong Hou, Liqing Yao, Yunshi Zhong, Ping-Chieh Chou, Wei Zhang, Pinghong Zhou, Yuhui Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01024-2

Internet

https://doi.org/10.1038/s41467-017-01024-2

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