The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

The nicotine-degrading enzyme NicA2 reduces nicotine levels in blood, nicotine distribution to brain, and nicotine discrimination and reinforcement in rats

Abstract Background The bacterial nicotine-degrading enzyme NicA2 isolated from P. putida was studied to assess its potential use in the treatment of tobacco dependence. Results Rats were pretreated with varying i.v. doses of NicA2, followed by i.v. administration of nicotine at 0.03 mg/kg. NicA2 ha...

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Bibliographic Details
Main Authors: Paul R. Pentel, Michael D. Raleigh, Mark G. LeSage, Thomas Thisted, Stephen Horrigan, Zuzana Biesova, Matthew W. Kalnik
Format: Article
Language:English
Published: BMC 2018-07-01
Series:BMC Biotechnology
Subjects:
Nicotine
Enzyme
Metabolism
Degradation
Addiction
Online Access:http://link.springer.com/article/10.1186/s12896-018-0457-7

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http://link.springer.com/article/10.1186/s12896-018-0457-7

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