Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs

Synthesis and Biological Evaluation of Novel 10-Substituted-7-ethyl-10-hydroxycamptothecin (SN-38) Prodrugs

In an attempt to improve the antitumor activity and reduce the side effects of irinotecan (2), novel prodrugs of SN-38 (3) were prepared by conjugating amino acids or dipeptides to the 10-hydroxyl group of SN-38 via a carbamate linkage. The synthesized compounds completely generated SN-38 in pH 7.4...

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Bibliographic Details
Main Authors: Mo Zhou, Meixia Liu, Xinhua He, Hong Yu, Di Wu, Yishan Yao, Shiyong Fan, Ping Zhang, Weiguo Shi, Bohua Zhong
Format: Article
Language:English
Published: MDPI AG 2014-11-01
Series:Molecules
Subjects:
antitumor agent
camptothecins
prodrugs
SN-38
Online Access:http://www.mdpi.com/1420-3049/19/12/19718

Internet

http://www.mdpi.com/1420-3049/19/12/19718

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