JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation

JQ-1 ameliorates schistosomiasis liver fibrosis by suppressing JAK2 and STAT3 activation

Schistosomiasis is a serious parasitic infection caused by Schistosoma. The parasite deposits eggs in the host liver, causing inflammation that activates hepatic stellate cells (HSCs), which leads to liver fibrosis. Currently, there is no effective therapy for liver fibrosis; thus, treatments are ur...

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Bibliographic Details
Main Authors: Han Ding, Xuhan Yang, Jiaming Tian, Xinran Wang, Yongsheng Ji, Saeed El-Ashram, Cuiping Ren, Jijia Shen, Miao Liu
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Schistosoma japonicum
Fibrosis
JQ-1
JAK2/STAT3
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221010659

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http://www.sciencedirect.com/science/article/pii/S0753332221010659

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