Design and synthesis of novel estrogen receptor antagonists with acetal containing biphenylmethane skeleton
Novel compounds bearing acetal groups in their biphenylmethane skeletons were synthesized in moderate yields from benzophenone derivative. Compound 1 did not exhibit antagonistic activity against the ERα estrogen receptor; however, compounds 2, 3, and 4 exhibited potent ERα antagonistic activities....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715621000291 |