Prediction of Function Determining and Buried Residues Through Analysis of Saturation Mutagenesis Datasets

Mutational scanning can be used to probe effects of large numbers of point mutations on protein function. Positions affected by mutation are primarily at either buried or at exposed residues directly involved in function, hereafter designated as active-site residues. In the absence of prior structur...

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Bibliographic Details
Main Authors: Munmun Bhasin, Raghavan Varadarajan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.635425/full