A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control

A poly-neoantigen DNA vaccine synergizes with PD-1 blockade to induce T cell-mediated tumor control

The combination of immune-stimulating strategies has the potency to improve immunotherapy of cancer. Vaccination against neoepitopes derived from patient tumor material can generate tumor-specific T cell immunity, which could reinforce the efficacy of checkpoint inhibitor therapies such as anti-PD-1...

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Bibliographic Details
Main Authors: Elena Tondini, Tsolere Arakelian, Koen Oosterhuis, Marcel Camps, Suzanne van Duikeren, Wanda Han, Ramon Arens, Gerben Zondag, Jeroen van Bergen, Ferry Ossendorp
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:OncoImmunology
Subjects:
dna vaccination
neoantigens
anti-pd-1
cancer immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2019.1652539

Internet

http://dx.doi.org/10.1080/2162402X.2019.1652539

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