Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni

Anti-Schistosomal Activity of Cinnamic Acid Esters: Eugenyl and Thymyl Cinnamate Induce Cytoplasmic Vacuoles and Death in Schistosomula of Schistosoma mansoni

Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1–30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show...

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Bibliographic Details
Main Authors: Jan Glaser, Uta Schurigt, Brian M. Suzuki, Conor R. Caffrey, Ulrike Holzgrabe
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Molecules
Subjects:
Schistosoma
schistosomula
parasite
eugenyl cinnamate
thymyl cinnamate
vacuoles
autophagy
anti-schistosomal activity
Online Access:http://www.mdpi.com/1420-3049/20/6/10873

Internet

http://www.mdpi.com/1420-3049/20/6/10873

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