Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain

Abstract Rapgef2 and Rapgef6 define a subfamily of guanine nucleotide exchange factors for Rap small GTPases, characterized by the possession of the Ras/Rap-associating domain. Previous genomic analyses suggested their possible involvement in the etiology of schizophrenia. We recently demonstrated t...

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Bibliographic Details
Main Authors: Kazuhiro Maeta, Satoko Hattori, Junji Ikutomo, Hironori Edamatsu, Shymaa E. Bilasy, Tsuyoshi Miyakawa, Tohru Kataoka
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Molecular Brain
Subjects:
Rap small GTPases
Guanine nucleotide exchange factors
Rapgef2
Rapgef6
Behavioral analysis
Schizophrenia
Online Access:http://link.springer.com/article/10.1186/s13041-018-0370-y

Internet

http://link.springer.com/article/10.1186/s13041-018-0370-y

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