Complex regulation controls Neurogenin3 proteolysis

Summary The ubiquitin proteasome system (UPS) is known to be responsible for the rapid turnover of many transcription factors, where half-life is held to be critical for regulation of transcriptional activity. However, the stability of key transcriptional regulators of development is often very poor...

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Bibliographic Details
Main Authors: Ryan Roark, Laura Itzhaki, Anna Philpott
Format: Article
Language:English
Published: The Company of Biologists 2012-10-01
Series:Biology Open
Subjects:
Online Access:http://bio.biologists.org/content/1/12/1264