Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation

Antitumor Effects of Vitamin D Analogs on Hamster and Mouse Melanoma Cell Lines in Relation to Melanin Pigmentation

Deregulated melanogenesis is involved in melanomagenesis and melanoma progression and resistance to therapy. Vitamin D analogs have anti-melanoma activity. While the hypercalcaemic effect of the active form of Vitamin D (1,25(OH)2D3) limits its therapeutic use, novel Vitamin D analogs with a modifi...

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Bibliographic Details
Main Authors: Tomasz Wasiewicz, Paulina Szyszka, Miroslawa Cichorek, Zorica Janjetovic, Robert C. Tuckey, Andrzej T. Slominski, Michal A. Zmijewski
Format: Article
Language:English
Published: MDPI AG 2015-03-01
Series:International Journal of Molecular Sciences
Subjects:
vitamin D
1,25(OH)2D3
vitamin D analogs
secosteroids
lumisterol melanoma
melanin pigmentation
anti-melanoma effect
Online Access:http://www.mdpi.com/1422-0067/16/4/6645

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http://www.mdpi.com/1422-0067/16/4/6645

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